The Effects of Moderate Hypothermia and Intrathecal Tetracaine on Glutamate Concentrations of Intrathecal Dialysate and Neurologic and Histopathologic Outcome in Transient Spinal Cord Ischemia in Rabbits
Anesth Analg 1999 88: 56-62.
[Abstract]
[Full Text]
Implications: Sodium channel blockers, including local anesthetics, have been shown to reduce glutamate release in brain ischemia and have a neuroprotective effect. However, in the present study, intrathecal tetracaine did not attenuate either glutamate release or the neurologic or histopathologic outcome in spinal cord ischemia, whereas moderate hypothermia did.