Pre- Versus Postinjury Effects of Intravenous GABAergic Anesthetics on Formalin-Induced Fos Immunoreactivity in the Rat Spinal Cord
Anesth Analg 1999 88: 414.
[Abstract]
[Full Text]
Implications: In this study, we examined whether IV general anesthetics (propofol, alphaxalone, and pentobarbital) prevent injury-induced spinal cord changes. We measured spinal Fos protein after rats received anesthetics before versus after a formalin injection. Fos inhibition patterns were inconsistent with behavioral studies of these anesthetics, suggesting that Fos inhibition does not always correlate with behavioral analgesia.