Enantioselectivity of Thiopental Distribution into the Central Neural Tissue of Rats: An Interaction with Halothane
Anesth Analg 1999 89: 230.
[Abstract]
[Full Text]
Implications: Because thiopental is a mixture of two forms (termed R- and S-enantiomers), correct interpretation of its distribution into, and clearance from, the body requires knowledge about both enantiomers. In this study, performed in rats, we showed that the two enantiomers of thiopental differed significantly, with the R-enantiomer having the preferred profile.