Implications: We evaluated the antiemetic efficacy, safety,and routine use of prophylactic ondansetron, a "gold standard"antiemetic, in women undergoing radical breast surgery who wereat a high risk of postoperative vomiting. We analyzed more meaningful"true" and "therapeutic" outcome measures, and we conclude thatprophylactic ondansetron is safe and effective and that itsroutine use is justified.
Implications: The goal of this study was to assess the relationshipbetween preoperative anxiety and intraoperative anesthetic requirements.We found that high baseline anxiety predicts increased intraoperativeanesthetic requirements. We suggest that anesthesiologists shouldmodify the initial induction dose based on the anxiety levelexhibited by the patient.
Implications: The length of postoperative stay among ambulatorysurgical patients is mainly determined by the type of surgeryand by adverse events, such as excessive pain, postoperativenausea and vomiting, dizziness, drowsiness, and untoward cardiovascularevents. Patients with congestive heart failure and those whounderwent long procedures had a higher risk of a prolonged stay.Appropriate prevention and management of postoperative symptomscould significantly decrease the length of stay among patientsreceiving general anesthesia.
Implications: Nitric oxide affects platelet function. We demonstratedthat nitric oxide delivered into the gas inflow of the cardiopulmonarybypass circuit membrane oxygenator does not significantly alterplatelet numbers or function.
Implications: Cervical plexus blockade for carotid endarterectomycan be effectively performed with a single injection after localizationof the cervical plexus with a nerve stimulator. This techniqueis simple and was associated with less systemic absorption oflocal anesthetic than the multiple-injection technique.
Implications: We studied gastric mucosal tonometry and the cytosolicliver enzyme {alpha}-glutathione S-transferase to evaluate the effectsof controlled hypotension induced by sodium nitroprusside onsplanchnic perfusion and hepatocellular integrity. Splanchnicperfusion decreased and {alpha}-glutathione S-transferase increasedduring and after a hypotensive period, but returned to baselinevalues within the first postoperative day, indicating a transientimpairment of splanchnic perfusion and hepatocellular integrity.
Implications: A sympathetic block in certain segments leadsto increased sympathetic output in unblocked segments. For anupper thoracic epidural block, this might lead to impaired splanchnicperfusion. In awake and propofol-anesthetized, chronically instrumenteddogs, however, a limited upper thoracic epidural blockade hadno compromising effect on gastrointestinal perfusion.
Implications: For total knee replacement, when compared withnormovolemic hemodilution, tranexamic acid administration isassociated with superior perioperative hemodynamic stabilityand allogeneic blood sparing.
Implications: Hypotensive episodes occur more frequently afteranesthetic induction in patients receiving Angiotensin II receptorsubtype-1 antagonists under anesthesia than with other hypotensivedrugs. They are less responsive to the vasopressors ephedrineand phenylephrine. The use of a vasopressin system agonist waseffective in restoring blood pressure when hypotension was refractoryto conventional therapy.
Implications: Life-threatening arrhythmias of the heart aftermyocardial infarction or ischemia may be treated quickly andefficiently by the new drug E 047/1.
Implications: Blood pressure is controlled partially by themyogenic response. This refers to the capacity of arteries todilate and then constrict in response to pressure increase.Using arteries from rabbits, we have shown that administrationof halothane reduces or abolishes this response. This observationmay be a contributing factor to hypotension caused by halothane.
Implications: The principal hemodynamic effect of propofol inchildren with congenital heart defects is a decrease in systemicvascular resistance. In children with cardiac shunt, this resultsin a decrease in the ratio of pulmonary to systemic blood flow,and it can lead to arterial desaturation in patients with cyanoticheart disease.
Implications: Ketamine has a negative inotropic effect in isolatedcardiomyocytes. The negative inotropic effect was associatedwith a decrease in inositol 1,4,5-trisphosphate production,and the inhibitory action was enhanced depending on the concentrationof extracellular Ca2+.
Implications: Long-term survival after cardiac arrest may bedetermined by the ability to ensure adequate organ perfusionduring cardiopulmonary resuscitation and in the postresuscitationphase. In this regard, small-dose dopamine improved postresuscitationblood flow to the mesenteric bed when vasopressin was used asan alternative vasopressor in an animal model of cardiac arrest.
Implications: Changes in cerebral blood flow caused by the changesof carbon dioxide tension are greater during the administrationof isoflurane anesthesia compared with sevoflurane anesthesia.Attempts to decrease intracranial pressure by decreasing carbondioxide tension may be more successful during isoflurane thansevoflurane anesthesia administration.
Implications: Isoflurane can reduce N-methyl-D-aspartate-mediatedcortical injury in vivo in a dose-dependent manner. These dataare consistent with the previously demonstrated ability of isofluraneto reduce N-methyl-D-aspartate receptor-mediated responses invitro.
Implications: We evaluated the mechanism of action of sodiumthiosulfide (STS) in sodium nitroprusside-induced cyanide toxicityin the ewe. Fetal cyanide poisoning is alleviated by maternaladministration of STS, although this cyanide antidote apparentlydoes not cross the placenta.
Implications: Determining the independent contribution of plateletsand fibrinogen to the maximal amplitude of thromboelastographyusing c7E3 Fab may further improve the use of thromboelastographyin detecting and treating coagulation defects.
Implications: Wound infiltration and lavage with 30 mL ropivacaine7.5 mg/mL after major shoulder surgery resulted in very lowpain scores and opioid requirement.
Implications: Insertion of a needle at the inguinal crease leveland immediately adjacent to the lateral border of the femoralartery results in a high rate of needle-femoral nerve contact.
Implications: Ropivacaine, a new local anesthetic, proved tobe effective for pain relief after hernia repair in ilioinguinalblocks accompanying general anesthesia. Plasma concentrationspeaked after 30-45 min, and were within safe limits afterapplication of 0.25 mL/kg of 2, 5, or 7.5 mg/mL ropivacaine.
Implications: A long-lasting nerve block can prevent early hyperalgesiacaused by nerve transection.
Implications: Using a tourniquet on the forearm for IV regionalanesthesia does not increase the risk of drug leakage. Thisis potentially a safer technique compared with conventionalIV regional anesthesia because a much smaller dose of localanesthetic is required.
Implications: A small dose of epidural morphine is often usedfor postoperative analgesia. We found that oral clonidine premedication5 {micro}g/kg improves the analgesic efficacy of epidural morphinewithout increasing the incidence of adverse side effects.
Implications: A rat model with chronically implanted epiduralcatheters should be used for testing the analgesic effects ofdrugs within two days after catheterization.
Implications: We demonstrated a significant additive effectof the combination of levobupivacaine (0.125%) and fentanyl(4 {micro}g/mL), compared with either drug alone, when usingpatient-controlled epidural analgesia in patients after totaljoint arthroplasty.
Implications: A significant improvement in postoperative analgesicefficacy is demonstrated with the thoracic epidural administrationof the combination of the single-isomer local anesthetic levobupivacaine0.25% and morphine 0.005% in patients after major abdominalsurgical procedures as compared with either drug used alone.
Implications: During topical application of the local anestheticropivacaine in dogs, hypocapnia (PaCO2, 20-25 mm Hg) inducedalmost no additional constriction of spinal arterioles, andthe hypercapnic vasodilation was maintained. These data suggestthat an additional constriction in spinal vessels is unlikelywhen hypocapnia occurs during spinal ropivacaine.
Implications: Combined stellate ganglion block and intraarterialor IV infusion of prostaglandin E1 increases brachial arterialblood flow significantly compared with stellate ganglion blockalone.
Implications: A change in the visual analog scale score representsa relative change in the magnitude of pain sensation. Use ofthe VAS in comparative analgesic trials can now meaningfullyquantify differences in potency and efficacy.
Implications: We investigated the peripheral effects of fentanyland ketamine on capsaicin-induced hyperalgesia and axon-reflexflare. In large concentrations, the opioid diminished axon-reflexflare without effects on secondary hyperalgesia. We found noevidence for the involvement of endogenous glutamate in secondaryhyperalgesia or axon reflex flare.
Implications: We performed a citation analysis to identify importantcontributions and contributors to the biomedical literature.Recent pain and analgesia research has been focused on mechanismsof pain, but evidence suggests the importance of understandingthe pain experience from the patient's perspective andthe transition from acute to chronic pain.
Implications: Intraperitoneally administered YM872, a new {alpha}-amino-3-hydroxy-5-methylisoxazole-4-propionicacid receptor antagonist, had analgesic effects on thermal-and formalin-induced pain in rats. Larger doses induced transientmotor disturbance and loss of pinna reflex mediated in the brain.
Implications: We found that a commercially available negativepressure rewarming device (ThermostatTM; Aquarius Medical Corp.,Phoenix, AZ) was not effective in accelerating rewarming inpostoperative hypothermic surgical patients after general anesthesia.
Implications: Under certain pathologic conditions, includingcerebral ischemia and traumatic brain injury, glutamate neurotoxicitymay initially be propagated by hypothermia due to relative failureof glutamate uptake via Human Glial Glutamate Transporter beforea subsequent recovery of uptake.
Implications: Amino acid infusion during general anesthesiainduces thermogenesis and prevents postoperative hypothermiaand shivering. Multiple regression analysis indicated that thisresulted in a shorter hospital stay.
Implications: Propofol is an effective IV anesthetic for theinduction and maintenance of anesthesia. Subhypnotic and anestheticdoses of propofol decrease diaphragmatic contractility in dogs.
Implications: Radioactive dye was injected IV into healthy volunteersto determine the time it took for the dye to appear in the duodenum.This was repeated under the influence of a short-acting narcoticanalgesic, remifentanil. Remifentanil caused a much shorterdelay than previously reported after morphine or meperidine.
Implications: Ulinastatin delays the onset of neuromuscularblock and hastens its recovery caused by vecuronium. This isbecause ulinastatin may release acetylcholine at the neuromuscularjunction and increase hepatic and/or renal clearance of vecuronium.
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