The Effect of
2 Agonist-Induced Sedation and Its Reversal with an
2 Antagonist on Organ Blood Flow in Sheep
Anesth Analg 2000 90: 1060-1066.
[Abstract]
[Full Text]
Implications: The {alpha}2 agonist, medetomidine, decreased and redistributed organ blood flow in sheep. Although the highly selective {alpha}2 antagonist, atipamezole, reversed medetomidine-induced hemodynamic changes, blood flow to the heart and kidney rmeoaned significantly depressed, whereas skeletal muscle blood flow increased to twice baseline values.