A Lack of Evidence of Superiority of Propofol Versus Midazolam for Sedation in Mechanically Ventilated Critically Ill Patients: A Qualitative and Quantitative Systematic Review
Anesth Analg 2001 92: 975-983.
[Abstract]
[Full Text]
Implications: The duration of adequate sedation time is longer with propofol compared with midazolam. In postoperative patients with sedation <36 h, weaning is faster with propofol. The clinical relevance of these differences remains unclear. Specific adverse effects are more common with propofol. For rational decision making, reliable data are needed on cost, mortality, intensive care unit populations other than postoperative, and long-term sedation.