Reduced Regional and Global Cerebral Blood Flow During Fenoldopam-Induced Hypotension in Volunteers
Anesth Analg 2001 93: 45-52.
[Abstract]
[Full Text]
Implications: In awake volunteers with (presumably) intact cerebral autoregulation,fenoldopam-induced hypotension significantly decreased global cerebral bloodflow (CBF). Clinicians should be aware of these pharmacodynamic effects whenchoosing a vasodilator to control blood pressure, especially in situationswhere control of CBF, cerebral blood volume, and intracranial pressure aretherapeutic priorities.