Implications: In this retrospective analysis, the influence of a continuous infusion of anendogenous hormone (arginine vasopressin) on systemic hemodynamics andlaboratory variables was assessed in patients with vasodilatory shockunresponsive to conventional therapy. Arginine vasopressin was effective inreversing systemic hypotension. However, adverse effects on gastrointestinalperfusion and coagulation cannot beexcluded.
Implications: Transesophageal echocardiography performed immediately before coronary arterybypass graft (CABG) surgery is not useful for prediction of susceptibility todevelop atrial fibrillation postoperatively. Postoperative atrial fibrillationcommonly occurs after CABG surgery in the absence of preoperative atrialenlargement or Doppler derived functional abnormalities.
Implications: This study suggests that protamine reversal of heparin's antiplateleteffect occurs within a narrow window because of the direct antiplateleteffects of protamine. Antithrombin effects may explain the inhibition of shearactivation of platelets by both heparin and protamine. Nonspecific chargeeffects of protamine may explain the inhibition of collagen plateletactivation in the presence of medium shear.
Implications: A modified activated clotting time test system that may be helpful inmonitoring hirudin anticoagulation in patients with heparin-inducedthrombocytopenia during cardiac surgery with cardiopulmonary bypass isdescribed.
Implications: Patients undergoing major surgery to the spine often acquire a perioperativecoagulopathy. The prothrombin time and activated partial thromboplastin timehad the greatest sensitivity and specificity for predicting bleeding in majorsurgery of the spine. The test values that differentiated normal fromexcessively bleeding patients could be used to guide transfusion therapyduring surgery.
Implications: Patients who have had a preoperative stroke may show asymmetry of theircortical baseline somatosensory evoked potential waveforms; however, this doesnot interfere with the ability to use somatosensory evoked potential as amonitor during surgery.
Implications: In awake volunteers with (presumably) intact cerebral autoregulation,fenoldopam-induced hypotension significantly decreased global cerebral bloodflow (CBF). Clinicians should be aware of these pharmacodynamic effects whenchoosing a vasodilator to control blood pressure, especially in situationswhere control of CBF, cerebral blood volume, and intracranial pressure aretherapeutic priorities.
Implications: After administration of terlipressin to treat hypotension related to induction of general anesthesia, profound hypertension occurred in association with myocardial ischemia and occlusion of the left anterior descending coronary artery. The authors emphasize cautious use of this drug because of such adverse events.
Implications: This report shows that if diffuse coronary thromboembolism is encounteredduring ascending aortic dissection-repair, the option of combiningsingle-bolus, intracoronary thrombolysis with intraaortic ballooncounterpulsation should beconsidered.
Implications: This case series describes the anesthetic problems and management of patients with pulseless disease.
Implications: Hand ventilation of the lungs in neonates has been used to detect changes inrespiratory compliance, but laboratory models have failed to demonstrate itsusefulness. We determined that pediatric anesthesiologists could detect 83% oftracheal tube occlusions in neonates if either the fresh gas flow was 2 L/minor the pediatric anesthesiologist was experienced (>8yr).
Implications: The addition of clonidine (0.08-0.12{micro}g{middle dot}kg-1{middle dot}h-1)to a continuous epidural infusion of ropivacaine was found to improvepostoperative pain relief in children. No clinically significant signs ofsedation or other side effects wereobserved.
Implications: The influence of age on the characteristics of spinal anesthesia is stillcontroversial. Our results show that adolescents develop blockade moreextensively and quickly than adults after spinal anesthesia with 0.5%tetracaine in 7.5% glucose but not after the 0.75% glucosesolution.
Implications: The administration of prophylactic tranexamic acid in patients with scoliosiswho are undergoing posterior spinal fusion surgery has the potential to reduceperioperative blood transfusion requirements.
Implications: A dose of 2.5 {micro}g/kg of fentanyl prevents emergence agitation associatedwith desflurane anesthesia in children undergoing adenoidectomy withoutdelaying emergence.
Implications: We conducted a randomized study in 147 pediatric patients undergoingcardiopulmonary bypass to determine when there are any differences inhemodynamic effects if CaCl2 20 mg/kg and protamine 5mg/kg are mixed together and infused over 10 min versus administering half ofthe calcium dose (10 mg/kg) as a bolus followed by a 10-min infusion ofprotamine 5 mg/kg and CaCl2 10mg/kg.
Implications: We describe the successful management of thoracoscopic thoracic duct ligation in a 2.5-kg compromised infant by using selective lobar-bronchial blockade. The technique reduces the risk of intraprocedural physiologic impairment, allowing the benefits of otherwise minimally invasive thoracoscopic procedures, even when the conditions of children are severely compromised.
Implications: The addition of EDTA does not alter the clinical profile of propofol inpediatric ambulatory surgical patients. With or without EDTA, propofol isassociated with a decrease in ionized calcium with no apparent clinicaleffect.
Implications: In this study, although 41%-94% of the patients were fast-track eligibleafter laparoscopic surgery, only 35%-53% of the patients actuallybypassed the postanesthesia care unit (PACU) because of anesthetic-relatedfactors and surgical complications. Residual sedation was the most commonanesthetic-related cause of failure to bypass thePACU.
Implications: We performed a randomized, controlled trial comparing the use of ketamine andmorphine with morphine alone to relieve pain after major abdominal surgery.Ketamine did not improve pain relief and merely increased sideeffects.
Implications: Epidural analgesia combined with general anesthesia prevented thehyperglycemic response to surgery by decreasing endogenous glucose production.The increased glucose plasma concentration in patients receivingfentanyl/midazolam anesthesia was caused by a decrease in whole-body glucoseclearance. The hyperglycemic response observed during inhaled anesthesia withisoflurane was a consequence of both impaired glucose clearance and increasedglucose production.
Implications: Complications related to cardiopulmonary bypass (CPR) are not increased whenCPR is administered by nonmedical personnel, as assessed by chest radiograph.These data may be valuable in motivating laypeople to perform basic lifesupport.
Implications: This study reports the medical and demographic risk factors associated withmaternal death during hospital admission for delivery by using astate-maintained database. This information could prove useful in the creationof initiatives aimed at decreasing the public health burden associated withmaternal mortality.
Implications: Hemoglobin solutions eliminate many limitations of blood transfusions. Ourresults show that fluid replacement with either blood or a hemoglobinsolution, compared with hetastarch, restored fetal oxygenation in pregnantewes after hemorrhage. If applicable to women, these results suggest apotential for the use of hemoglobin solutions in obstetrics.
Implications: Uterine and umbilical blood flows are determinant features in controlling theplacental transfer of propofol, and, therefore, changes in these variableswould significantly affect the extent of fetal exposure topropofol.
Implications: Eighteen milligrams of 0.5% hyperbaric ropivacaine provided effective spinalanesthesia with shorter duration of sensory and motor block, compared with 12mg of 0.5% hyperbaric bupivacaine when administered for cesareandelivery.
Implications: Nalbuphine was superior to propofol for the treatment of intrathecalmorphine-induced pruritus after cesarean delivery.
Implications: We measured brain arteriovenous shunting and tissue oxygen pressure(PtO2)during a 40% decrease in blood pressure induced by sodium nitroprusside (SNP)or 3% isoflurane. Large-dose isoflurane maintainedPtO2 withno change in shunting. SNP infusion decreasedPtO2 50%and increased shunting 50%. This suggests that SNP-induced hypotensiondecreasesPtO2because of a decrease in capillaryperfusion.
Implications: When compared with the established test of static autoregulation, thetransient hyperemic response test provides a valid method for assessing gradedimpairment in cerebral autoregulation.
Implications: Although {alpha}-human atrial natriuretic peptide (HANP) and milrinone each havea direct vasodilator effect on cerebral pial arterioles, their systemicadministration at clinical doses could have different effects andblood-brain-barrier disruptive conditions could alter the response of pialvessels to HANP, but not to milrinone.
Implications: We evaluated the effects of using a single- or multiple-injection technique onthe volume of 0.5% ropivacaine required to block the femoral nerve. The 95%effective concentration values for producing the same degree of sensory andmotor blockade of the femoral nerve within 20 min after injection were 29 mLafter elicitation of a patella twitch and 21 mL when the three main branchesof the femoral nerve were identified, potentially leading to an importantbenefit for patients receiving peripheral nerve blocks.
Implications: This study compares two local anesthetics to determine which is most suitablefor day-stay upper-limb surgery under axillary brachial plexus block.Prilocaine 1% is more suitable than ropivacaine 0.5% because of a moreprolonged duration of action of ropivacaine, although this could be useful inother circumstances.
Implications: Because of no differences in postoperative pain or opioid consumption, weconclude that a preoperative dose of 200 mg amantadine IV fails to enhancepostoperative analgesia in patients undergoing elective abdominalhysterectomy.
Implications: Spinal morphine interacts with systemic morphine or buprenorphine in asupraadditive manner. This mode of interaction most probably results from thesimultaneous activation of spinal and supraspinal antinociceptive systems.Supraspinal structures played a more important role in the antinociceptiveeffect of experimental combinations than structures of the spinal cord.
Implications: The chronic administration of opioids followed by abrupt cessation can lead toa state of hyperalgesia. In these studies we demonstrate that the hyperalgesiafrom opioid cessation and from hind paw incision are additive in rats. Wesuggest that failure to take into consideration preoperative opioid use canlead to excessive postoperative pain.
Implications: Our case suggests that gripping an epidural catheter with a hemostat duringthe removal might result in accidental breakage of the catheter. Todemonstrate the effect of the use of a hemostat, tensile strengths ofcatheters were measured while they were being held with either a stainlesssteel or rubber-sleeved hemostat.
Implications: In this article we discuss the development of epidural needles and thehistorical factors leading to their invention. The most popular needles aredescribed and their inventorsacknowledged.
Implications: The CO2 absorption capacity of Amsorb(R) is half that of Medisorb(R) and Sodasorb(R) under clinical low-flow (1 L/min) anesthesia with either a 750-mL Ohmeda ADU compact or a 1350-mL Ohmeda Aestiva 3000 canister.
Implications: Resting gastroesophageal barrier pressure and upper esophageal sphincterpressure are unaffected by oropharyngeal topical anesthesia and laryngeal maskdevices in awake subjects, but deglutition frequency is increased by laryngealmask devices. This may have implications for the incidence of regurgitation inthese situations.
Implications: We compared the relaxant effects of olprinone and aminophylline onmethacholine-induced bronchoconstriction in dogs. The relaxant effects ofolprinone are independent of plasma epinephrine, whereas the aminophyllineeffects may be partly caused by an increase in plasmaepinephrine.
Implications: Volatile anesthetics are often used during hypothermic conditions, and tissuesolubility of volatile anesthetics is an important determinant for the wash-inand washout of the anesthetics in tissue. Tissue/gas partition coefficientsduring hypothermia have implications for understanding the pharmacokinetics ofvolatile anesthetics at hypothermicconditions.
Implications: An intraoperative arterial stimulation, venous sampling method was recently used for resection of insulinoma. In using this technique, some anesthetic concerns complicate the usual management of insulinoma. We suggest methods for solving these problems.
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