IMPLICATIONS: Many anesthesiologists believe that thoracic epidural anesthesia/analgesia (TEA) is contraindicated for cardiac surgery because of increased risk of paraplegia. However, this large prospective study confirms that perioperative morbidity is significantly less with TEA and suggests that the practical benefits may outweigh the unquantified risk of epidural hematoma.
IMPLICATIONS: This trial of plateletpheresis in reoperative coronary artery surgery was performed to assess its effect on allogeneic blood product transfusion. Routine antifibrinolytic usage, minimal aspirin, and nonbiologic surface exposure seem to negate any benefit of the technique in these patients. These findings differ from those of other recent reports. The study also emphasizes the potential hemodynamic disturbances related to the pheresis process.
IMPLICATIONS: In isolated human right atria, remifentanil, sufentanil, and fentanyl did not modify inotropic variables in isometric conditions. In contrast, alfentanil induced a concentration-dependent negative inotropic effect possibly related, at least in part, to a decrease in Ca2+ inward transient. None of these opioids altered lusitropic variables.
IMPLICATIONS: Propofol was shown to exert direct negative inotropic effects in nonfailing and failing human myocardium, but only at supratherapeutic concentrations. The net effect on contractility at clinical concentrations is related to an increase in myofilament sensitivity to Ca2+ balancing decreased uptake by the sarcoplasmic reticulum.
IMPLICATIONS: In patients undergoing carotid endarterectomy, the induction of anesthesia with sevoflurane, target-controlled infusion propofol, or propofol bolus is associated with a decrease in arterial blood pressure. Induction with sevoflurane is associated with inferior but faster conditions for intubation of the trachea. The recovery characteristics were similar in the three groups.
IMPLICATIONS:Leukocytes contained in intraoperatively processed autologous blood using either heparin or citrate were not activated to the threshold that is associated with leukocyte-mediated tissue injury. This study raises the question of the necessity of special leukocyte filters for the transfusion of intraoperatively salvaged blood.
IMPLICATIONS: Decision analysis indicates that continued aspirin use in patients undergoing infrainguinal revascularization surgery is associated with a decreased perioperative mortality and increased life expectancy but may increase the likelihood of minor hemorrhagic complications.
IMPLICATIONS: This report suggests that rapid desensitization accounts for the transient increase in blood pressure observed after IV administration of {micro}-opioid agonists, and that the rate of resensitization is a function of the elimination half-life of the agonist.
IMPLICATIONS: We have evaluated nitrous oxide and EMLA cream for providing pain relief during venous cannulation in children at the induction of anesthesia. Both techniques provided adequate pain relief, and physiologic variables were not altered. Minor side effects were more common in the N2O group.
IMPLICATIONS: This study demonstrates that an interscalene brachial plexus block with 1.5% mepivacaine and a continuous intraarticular infusion of 0.5% ropivacaine at 2 mL/h provides better postoperative analgesia for arthroscopic shoulder surgery at 24 and 48 h than does a single-injection interscalene block with 0.5% ropivacaine.
IMPLICATIONS: Intraoperative small-dose ketamine proved a safe and effective adjunct to a multimodal analgesic regimen, improving both postoperative analgesia and functional outcome after outpatient arthroscopic meniscectomy.
IMPLICATIONS: Adoption of Bispectral index monitoring throughout an entire operating room was associated with use of lesser concentrations of sevoflurane to maintain anesthesia and reduced recovery duration in men undergoing general anesthesia for ambulatory surgery.
IMPLICATIONS: The activation of neither {kappa}-opioid nor central anticholinergic receptors contributes to meperidine's special antishivering action. Some other aspect of meperidine's pharmacology is thus responsible for the drug's special antishivering action.
IMPLICATIONS: Clinically relevant bupivacaine concentrations inhibit prostaglandin E2 EP1 subtype signaling. This may explain the effects of regional anesthesia on physiologic responses such as fever, inflammation, and hyperalgesia during the perioperative period.
IMPLICATIONS: Halothane and sevoflurane inhibit platelet aggregation. Xenon did not affect platelet glycoprotein expression or in vitro bleeding time. Because platelet glycoprotein expression is strongly related to platelet adhesion to sites of vascular injury and platelet aggregation, we suggest that xenon does not interfere with platelet function in vitro.
IMPLICATIONS: This study describes a new inspiratory impedance valve that is attached to a facemask or breathing tube and used during cardiopulmonary resuscitation. The valve helps to draw more blood back into the heart after each chest compression. In a pig study of cardiac arrest, use of this new valve resulted in a doubling of the blood flow to the heart and a near normalization of blood flow to the brain. Clinical studies are underway to determine the potential benefit of this more efficient way to perform cardiopulmonary resuscitation in patients.
IMPLICATIONS: Data were collected from trainees learning endotracheal intubation. Statistical modeling of the data enabled the identification of factors influencing learning and provided insight into the learning process. The knowledge gained can be used to improve teaching methods.
IMPLICATIONS: Hospital profitability of surgical cases varies significantly by surgeon. Hospitals may be able to increase margins by allocating operating room block time based on contribution margin.
IMPLICATIONS: The pathophysiologic role of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in critically ill patients is not clear. It is generally assumed that ANP and BNP have similar physiologic effects. We found a different secretion pattern in our patients, and this finding suggests a distinct role for ANP and BNP in the postoperative and posttraumatic period.
IMPLICATIONS:31P magnetic resonance spectroscopy of forearm muscles in subjects having developed exertional heat stroke shows a failure in muscle energetics and suggests a possible link with malignant hyperthermia.
IMPLICATIONS: We tested the influence of atracurium and cisatracurium on proliferation of human cells (hepatoma HepG2 cells and human umbilical vein endothelial cells) in vitro. Atracurium and cisatracurium progressively decreased cell proliferation in a concentration-dependent pattern, whereas cell proliferation was not inhibited, even by the largest concentration of mivacurium.
IMPLICATIONS: In cerebral arterioles in dogs under pentobarbital or isoflurane anesthesia, neither topical nor IV ketamine induced vasodilation. However, IV ketamine did attenuate hypercapnia-induced vasodilation. These findings provide some insight into the safety and suitability of ketamine as a supplement for neurosurgical anesthesia.
IMPLICATIONS: In patients receiving spinal anesthesia for elective cesarean delivery, when arterial pressure was maintained using an IV infusion of metaraminol, crystalloid bolus reduced the early vasopressor requirement but had no effect on overall vasopressor requirement or maternal or neonatal outcome.
IMPLICATIONS: The use of a computer-based decision support system may improve the ability of primary care physicians to manage chronic pain and may also facilitate screening of consults to optimize specialist utilization.
IMPLICATIONS: Preoperatively administered antiinflammatory analgesics should theoretically prevent the upregulation of nociception and inhibit inflammation and pain by reducing the synthesis of prostaglandins in response to surgery. The findings of this study demonstrate that preoperative administration of parecoxib sodium is both safe and effective for the treatment of pain after oral surgery.
Implications: In a rodent model of allodynia, where pain is triggered by nonpainful stimuli, hair deflection evokes release of spinal prostaglandin E2, locus coeruleus activation, and a blood pressure increase. A mediator role of nitric oxide is also implicated, helping to explain the pathophysiology of this allodynic pain.
IMPLICATIONS: We evaluated the effects of repeated dosages of epinephrine versus vasopressin in a porcine cardiac arrest model with epidural anesthesia. Both epinephrine and vasopressin increased coronary perfusion pressure sufficiently in this setting. Vasopressin may be more desirable during epidural block because the response to a single dose is longer lasting and because acidosis after multiple doses is less severe compared with epinephrine.
IMPLICATIONS: We compared the systemic toxicity induced by constant infusions of bupivacaine, levobupivacaine, and ropivacaine in anesthetized rats. The systemic toxicity of levobupivacaine was less than that of bupivacaine but more than that of ropivacaine. Ropivacaine-induced cardiac arrest was more susceptible to treatment than that induced by bupivacaine or levobupivacaine.
IMPLICATIONS: In young and old patients, we evaluated the cardiovascular effects and spread of numbness achieved from injection of local anesthetic (lidocaine 100-180 mg) into the thoracic epidural space and concluded that the smaller dose was quite effective and possibly safer, particularly in older patients.
IMPLICATIONS: The addition of epinephrine 1:400,000 or 1:200,000 to epidural 0.5% levobupivacaine reduces the resultant serum levobupivacaine levels without altering the duration of sensory blockade. All solutions were well tolerated and effective in producing epidural anesthesia for patients undergoing lumbar spine surgery.
IMPLICATIONS: A metaanalysis was performed to study the effects of morphine, injected intraarticularly, on postoperative pain during 24 h. Nineteen studies could be identified in which data were presented in such a way that metaanalysis could be performed. The results indicate a mild analgesic effect that could be dose dependent, but a systemic effect could not be ruled out.
IMPLICATIONS: The addition of clonidine to local anesthetics prolongs the duration of sensory block in the nerves. Such a finding could have interesting clinical applications in ambulatory or planned surgery in which motor function is best maintained.
IMPLICATIONS: We studied the relationship between tourniquet time and number of pulmonary emboli in 30 patients undergoing arthroscopic knee surgeries, by using transesophageal echocardiography. These data suggest that acute pulmonary embolism may occur within 1 min of the tourniquet release and that the number of emboli is related to tourniquet time.
IMPLICATIONS: Normal and malignant hyperthermia-susceptible swine gracilis muscle samples remain viable and accurately predict malignant hyperthermia susceptibility by caffeine halothane contracture test at 24 h after excision when they are clamped under tension and stored or shipped to another testing center in Krebs solution at room temperature.
IMPLICATIONS: Cricoid pressure is used for prevention of gastric regurgitation under general anesthesia. We found that cricoid pressure can increase the blood pressure and heart rate significantly.
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