The Inhibitory Effects of Anesthetics and Ethanol on Substance P Receptors Expressed in Xenopus Oocytes
Anesth Analg 2002 94: 79-83.
[Abstract]
[Full Text]
IMPLICATIONS: We examined the effects of halothane, isoflurane, enflurane, diethyl ether, and ethanol on substance P receptor (SPR) expressed in Xenopus oocytes, by using a whole-cell voltage clamp. All the anesthetics and ethanol inhibited SPR function, and the protein kinase C (PKC) inhibitor abolished these inhibitions. These results suggest that anesthetics and ethanol inhibit SPR function via PKC.