IMPLICATIONS: This study was a retrospective review of 85 patient charts that found a low cost-effectiveness of using American College of Cardiology/American Heart Association guidelines for obtaining preoperative dobutamine stress echocardiograms. Suggested modifications of these guidelines should improve their specificity with no loss in sensitivity.
IMPLICATIONS: In patients undergoing coronary artery bypass graft surgery, intraoperative low-dose dobutamine echocardiography has only limited value for the prediction of regional myocardial function at 1 yr. Small-dose dobutamine echocardiography predicts regional myocardial function at 1 yr when baseline regional wall motion abnormalities improve with dobutamine; however, the test cannot be used to predict which segment will not recover at 1 yr.
IMPLICATIONS: Mitral propagation velocity (Vp) is a simple, reproducible measure of diastolic function during coronary artery bypass graft surgery that correlates with standard Doppler echocardiographic techniques to identify dysfunction in the setting of a rapid heart rate or variable preload. Vp <50 cm/s identifies abnormal diastolic function in this patient population.
IMPLICATIONS: In a randomized, double-blinded, prospective clinical study, we compared the effect of adding small-dose ketamine to opioids during general anesthesia on superoxide production and showed that ketamine suppressed the increase of superoxide anion production by neutrophils after coronary artery bypass grafting.
IMPLICATIONS: In 412 patients, we determined that the incidence of nonsustained ventricular tachycardia after major thoracic surgery is 15% and is not associated with poor outcome.
IMPLICATIONS: Dependency of the pharmacokinetics of hydroxyethyl starch 130/0.4 on renal function was studied. The area under the time concentration curve increased moderately with more severe renal dysfunction; however, small plasma concentrations were observed after 24 h. Terminal half-life and peak concentration remained unaffected by renal impairment.
IMPLICATIONS: We describe an unusual case of acute ST segment increase secondary to warm saline thoracic cavity irrigation during thoracotomy. Temperature-mediated alteration of myocyte repolarization should be considered in addition to myocardial ischemia when ST segment changes occur.
IMPLICATIONS:A patient with catecholaminergic polymorphic ventricular tachycardia required anesthesia for implantation of a defibrillator. The diagnostic criteria, treatment, and anesthetic considerations for this rare, familial dysrhythmia are described.
IMPLICATIONS: Airway compression from insertion of a transesophageal echocardiography (TEE) probe has been mostly limited to pediatric patients. We present a case of TEE-associated airway obstruction in an adult patient undergoing surgery for repair of a giant ascending aortic pseudoaneurysm.
IMPLICATIONS: Transesophageal echocardiography (TEE) has not been used during airway manipulation to assess the occasional occurrence of hemodynamic instability that occurs especially in cardiac patients. We describe a new technique using an endoscopy mask to perform TEE monitoring during airway manipulation with a large concentration of supplemented oxygen.
IMPLICATIONS: Internal jugular vein cannulation is a frequently performed procedure. We present a case with a review of the literatures of subclavian artery injury secondary to this procedure, recognizing that this complication may be a right-sided phenomenon secondary to its unique anatomical layout.
IMPLICATIONS: The differential diagnosis of extracavitary, intramural and intracavitary disease may be difficult. An extrinsic compression of the left atrium by a dissecting pericardial hematoma was misdiagnosed as an intracavitary mass, by echocadiography and computer tomography. This case emphasizes the importance of patient history and clinical setting.
IMPLICATIONS: Tension pneumothorax during one-lung ventilation can be a life threatening emergency. Clinical diagnosis may be confusing in the operative setting. We present a case in which fiberoptic bronchoscopy excluded tube malpositioning and lead us to the diagnosis of a tension pneumothorax.
IMPLICATIONS: The results of this study suggest that the immobilizing actions of general anesthetics do not result from the inhibition of {alpha}4ß2 neuronal nicotinic acetylcholine receptors. However, the inhibition of neuronal nicotinic acetylcholine receptors may account for the amnestic activities of general anesthetics and nonimmobilizers.
IMPLICATIONS: We tested two mouse lines with glycine receptor mutations to determine whether glycine receptors might play an important role in anesthetic responses in vivo. Both sensitivity and resistance to common anesthetics were observed in mutant mice, depending on the behavioral end-point evaluated.
IMPLICATIONS: Adhesion of neutrophils to endothelial cells in reperfusion injury is mediated by different adhesion molecules. This study indicates that the inhibiting effect of isoflurane on neutrophil recruitment may be mediated by a decreased activation of the L-selectin and by attenuation of the activation of the ß2-integrins CD11a and CD11b.
IMPLICATIONS: We performed a pharmacokinetic/pharmacodynamic modeling study in myasthenic patients and control patients. The unbound receptor model, which takes into account the number of unbound acetylcholine receptors in the biophase, was introduced and compared with the model proposed by Sheiner.
IMPLICATIONS: Given as a target-controlled infusion for thyroid surgery, sufentanil 0.3 ng/mL for intubation and 0.2 ng/mL during surgery, combined with propofol 4 {micro}g/mL (corresponding to a maintenance infusion rate of approximately 7-10 mg {middle dot} kg-1 {middle dot} h-1), is recommended to ensure both optimal intraoperative stability and fast recovery.
IMPLICATIONS: Magnesium sulfate, 2.48 mmol, injected 20 s before the administration of propofol significantly reduced the incidence of pain caused by a propofol injection and may be useful in minimizing this common side effect.
IMPLICATIONS: The two experimental designs (quantal and bracketing) used for population minimum alveolar anesthetic concentration studies give equivalent results. An expression relating variability in terms of Hill coefficients and SD is presented. Evolutionary implications of low population variability in anesthetic phenotypes is discussed.
IMPLICATIONS: To successfully intubate 80% of children by using sevoflurane and no muscle relaxant, induction times of 137 and 187 s were needed in children of 1-4 yr and 4-8 yr, respectively.
IMPLICATIONS: We describe the anesthetic management of a pediatric patient who underwent thoracotomy repair of a colobronchial fistula. Single-lung ventilation confirmed the diagnosis and the position of the fistula. In addition, the intraoperative use of high frequency oscillatory ventilation in combination with conventional ventilation of the nonoperative side is described.
IMPLICATIONS: Transesophageal echocardiography may be useful in guiding detection and removal of thorax penetrating objects and for the monitoring of complications after removal of such objects.
IMPLICATIONS: Moderate to severe pain is common after ambulatory surgery and is a frequent cause of delayed discharge. Postoperative pain, opioid-related side effects, and time to discharge were less when nonsteroidal antiinflammatory drugs or local anesthetics were used intraoperatively to prevent pain before patient awakening.
IMPLICATIONS: Many devices serve as portable systems for IV equipment but are expensive and use complex electronic controls. We present a novel device to facilitate safe ambulation of IV-dependent patients. This device was effective in delivering required therapeutic flow rates over time periods desired for unattended operation.
IMPLICATIONS: In this prospective, randomized study, bispectral index (BIS), hemodynamics, time to extubation, and costs of target-controlled infusion (TCI) and manually-controlled infusion of propofol were compared. TCI increased the amount of propofol used. BIS failed to predict the adequacy of anesthesia for the next painful stimulus.
IMPLICATIONS: Acoustic reflectometry, a noninvasive test that uses sound to produce a length versus cross-sectional area map of the airway, was not able to predict inability to intubate, poor glottic visualization, and multiple laryngoscopies.
IMPLICATIONS: In an in vitrostudy, carbon dioxide (CO2) absorption capacity and possible carbon monoxide (CO) formation were tested in different absorbent brands. Absorbents with very small CO formation are not necessarily poor CO2 absorbents.
IMPLICATIONS: Chronic exposure to trace levels of anesthetic gas is harmful to operating room personnel, especially in the delivery of pediatric general anesthesia via an uncuffed endotracheal tube. The anesthetic scavenging hood is a cost-effective and efficient method to reduce these waste anesthetic gases, and it offers patient heat conservation.
IMPLICATIONS: Magnesium occurs naturally in the spinal cord and blocks the NMDA glutamate channel. In animal studies, intrathecal magnesium sulfate improves spinal morphine analgesia. For patients receiving spinal analgesia for labor, the addition of magnesium sulfate to the opioid fentanyl prolonged analgesia with no increase of side effects.
IMPLICATIONS: Parecoxib, a parenteral cyclooxygenase-2 inhibitor intended for perioperative use as an analgesic/antiinflammatory drug, is a substrate for hepatic cytochrome P450 3A4. The potential for a drug interaction with midazolam, an in vivo CYP3A4 probe, was tested in healthy volunteers. Single-bolus parecoxib does not alter the pharmacokinetics or pharmacodynamics of midazolam.
IMPLICATIONS: We present a retrospective data analysis to evaluate the predictive power of different ventricular fibrillation electrocardiogram variables in pigs with respect to defibrillation outcome. We showed that our combination of variables leads to an improved forecast, which may help to reduce harmful unsuccessful defibrillation attempts.
IMPLICATIONS: We tested, in a double-blinded manner, the hypothesis that acupressure could be an effective pain therapy in minor-trauma patients. Our results show that acupressure is an effective and simple-to-learn treatment of pain in emergency medical care and can improve the quality of care.
IMPLICATIONS: The effect of adding 75 {micro}g of clonidine to ropivacaine for epidural labor analgesia was studied. Clonidine increased analgesia duration and produced dose sparing compared with ropivacaine alone. Despite a tendency for hypotension in women receiving clonidine, there was no apparent effect on delivery mode or neonatal outcome.
IMPLICATIONS: Epidural ropivacaine potency in labor can be increased by the addition of epidural clonidine. This study demonstrates that 60 {micro}g of epidural clonidine significantly decreases the minimum local analgesic concentration of ropivacaine during the first stage of labor but is associated with sedation.
IMPLICATIONS: This randomized trial suggests that adding regular doses of naproxen to conventional "on request" acetaminophen and codeine therapy provides small reductions in pain on the second day after cesarean delivery. The greatest effects occur at 36 h, when pain peaks.
IMPLICATIONS: Combined deep and superficial cervical plexus block is an effective technique to reduce opioid requirements during and after thyroid surgery.
IMPLICATIONS: We evaluated the efficacy and safety of small-dose IM phenylephrine for prophylaxis against spinal anesthesia-induced hypotension in normotensive and hypertensive elderly patients. Phenylephrine 1.5 mg IM was effective for reducing the incidence of hypotension and avoided adverse effects.
IMPLICATIONS: The occurrence of transient neurologic symptoms after hypobaric lidocaine spinal anesthesia has not been reported, and may suggest sciatic stretch with neural ischemia rather than maldistribution as the cause of this syndrome.
IMPLICATIONS: We report a previously undescribed complication of peripheral nerve catheter placement. The catheter was sheared when its stylet was removed with the placement needle still in the tissues. The lost distal fragment was identified with computed tomography scanning.
IMPLICATIONS: Unsolicited paresthesias may occur when a nerve stimulator is used and may indicate valid proximity to the nerve. This phenomenon suggests that nerve stimulator use does not protect against unplanned direct contact with peripheral nerves during performance of a nerve block on an obtunded patient.
IMPLICATIONS: Ventilatory driving pressure during supraglottic high-frequency jet ventilation may be reduced to minimize high airway pressures and hence the potential for pulmonary barotrauma in patients with laryngotracheal stenosis.
IMPLICATIONS: The laryngeal mask airway ProSealTM offers advantages over the laryngeal tube airway in most technical aspects of airway management in paralyzed patients undergoing pressure-controlled ventilation.
IMPLICATIONS: We report a patient who developed myoclonic seizure in the postanesthesia care unit after thoracic laminectomy. Expeditious diagnostic evaluation of unrecognized dura tear during surgery must be instituted immediately to avoid untoward sequelae. Specific treatment in addition to supportive care is required if the diagnosis is to be clearly identified.
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