The Soluble Guanylyl Cyclase Inhibitor ODQ, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, Dose-Dependently Reduces the Threshold for Isoflurane Anesthesia in Rats
Anesth Analg 2004 99: 752-757.
[Abstract]
[Full Text]
IMPLICATIONS: The nitric oxide-guanylyl cyclase signaling pathway has been proposed to be involved in sedation, analgesia, and anesthesia. Specific inhibitors of the enzyme nitric oxide synthase resulted in a reduction in the anesthetic requirements (MAC) for isoflurane. In the present study, we demonstrate that ODQ, a specific inhibitor of soluble guanylyl cyclase, was also capable of reducing the MAC for isoflurane anesthesia in the rat.