Anesth Analg 2008 106: 1440-1449.
[Abstract]
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IMPLICATIONS: In local anesthetic toxicity models, the influence of general anesthesia has long demanded systematic study as an experimental variable. In our whole body ovine model, anesthesia affected survival, central nervous system, and cardiovascular system responses and, as described in this paper, pharmacokinetics. This demonstration of profound influences of anesthesia as an experimental variable has fundamental implications for the interpretation of local anesthetic toxicity, and for pharmacologic study design in general.