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Gary R. Strichartz, PhD
Editor
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My research interests center on the mechanisms that underlie persistent pain, including neuropathic pain from nerve injury and inflammation, from surgical procedures and from cancer. My earlier work focussed on the pharmacology of ion channels in excitable membranes and has evolved into the use of drugs targeted at these ion channels and other receptor/targets in order to prevent, ameliorate or reverse pain. At present much of this work involves the mammalian peripheral nervous system, the skin and the spinal cord, the various effects, acute and long-term, of local and systemic drugs and the modulation of excitability-controlling ion channels through second messengers activated by receptors for prostanoids, opiates and endothelin. The role of changes in excitability and coding properties of peripheral nerves in neuropathic states and in normal sensory processing is being investigated by classical in vivo neurophysiological single-unit recording, by patch-clamp methods, by calcium- imaging methods in cultured and primary cells, and by the tools of molecular biology. In addition, he continues to explore the use of natural and synthetic compounds as new classes of local anesthetic and analgesic agents acting on peripheral nerves.
| Consultant and conducting sponsored research for Orthocon, Inc, Colts Neck NJ.
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